Which genes are expressed in a quiescent stem cell?
Examples of genes that are downregulated in all three quiescent cell types (HSCs, MuSCs and HFSCs) include genes encoding cyclin A2, cyclin B1, cyclin E2 and survivin, which control various aspects of cell cycle progression15,43,45. Cyclin A2 and cyclin E2 are important regulators of cell cycle checkpoints46,47.
Use the diagram to determine which genes are expressed in a quiescent stem cell
What are quiescent stem cells?
Definition. Quiescence is the reversible state of a cell in which it does not divide but retains the ability to re-enter cell proliferation. Some adult stem cells are maintained in a quiescent state and can be rapidly activated when stimulated, for example by injury to the tissue in which they reside.
use the diagram to determine which genes are expressed in a quiescent stem cell
How are stem cells related to gene expression?
Cells differentiate, or become different from one another, by turning certain genes on and off. This process is called gene expression. Stem cells have the ability to turn into any other type of cell in the body, an ability known as pluripotency. Your body retains some stem cells for your entire life.